Antibiotic ResistanceM
The rise of antibiotic resistant bacteria threat public health world-wide. Over-use of antibiotics accelerates domination of resistant bacteria. Every year, over 700,000 patients are dying through antibiotic resistant bacterial infections. WHO warned that over 10,000,000 people will be dead by resistant infections a year by 2050 without direct action plan for antibiotic resistant. Since failures of new antibiotic developments, we face severe threats by antibiotic resistants. Wold-wide, alternative strategies are developed to solve AMR accumulation (e.g., Genome-editing technique, bacteriophage, endolysins, antibiotic adjuvants, etc.
Our lab focuses on,
- Development of novel antibiotics
- Finding Antibiotic adjuvant
- Alternative strategies to kill resistant
Bacterial Persistence
Antibiotic resistance is not the only mechanism employed by a bacterial cell to survive antibiotic exposure. Persistence is another important, basal, defense mechanism. Unlike the resistant cell, a persistent cell is genetically susceptible to an antibiotic while being phenotypically tolerant. Persister pathogens are one of the causes of chronic infectious diseases, leading to the overuse of antibiotics and the emergence of antibiotic-resistant bacteria. In addition, the supportive role of antibiotic tolerance in the evolution of resistance and promotion of antibiotic resistance evolution by bacterial persistence have been observed.
Our lab focuses on,
- Mechanism of persister cell formation
- Eradication of persister cell
- Regulation of persister cell formation
Microbiome
Recently, the evidences of relationship between human disease and gut microbiome are accumulated dramatically. In addition, it is revealed that soil microbiome composition is important in agriculture (crop). Because of many reasons (environmental factors - particular matters, antibiotics, food etc.), gut or soil microbiome alter their composition and sometimes, cause severe problem in host (human, animal, and plant). Understanding and remodeling microbiome are fast-growing in clinical and industrial area.
Our lab focuses on,
- Gut or Soil microbiome dysbiosis by environmental factors
- Molecular factors in microbiome dysbiosis
- Microbiome remodeling
Microbial communication
Like human, microbe talks to others to let them know what situation they are in now. By quorum-sensing and volatile compounds, one microbe affects to other microbe and induce their physiological changes. These communications are not only between microbe-microbe but also between microbe-host. Microbes talk to human or plant hosts and alters in good way (beneficial microbe) or in bad way (harmful microbe). By understanding and regulation of microbial communication, various applications are available.
Our lab focuses on,
- Microbe-Microbe interaction
- Microbe-Host interaction
- Regulate microbial communications
